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human il 4 interleukin 4  (Novoprotein)

 
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    Novoprotein human il 4 interleukin 4
    Human Il 4 Interleukin 4, supplied by Novoprotein, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+il+4+interleukin+4/4+interleukin/pm42086580-206-43-47
    Average 86 stars, based on 1 article reviews
    human il 4 interleukin 4 - by Bioz Stars, 2026-10
    86/100 stars

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    Incubation:

    Article Title: ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8 + T cell immunity.
    Article Snippet: .. Briefly, 5 × 106/ml PBMCs were enriched by plastic adherence in six-well plates at 37 °C and 5% CO2 Following 16 h incubation, the adherent cells were cultured in RPMI-1640 medium with 10% FBS, 50 ng/ml human GM-CSF (SJA01; Amoytop), and 10 ng/ml human IL-4 interleukin-4 (GMP-CD03; Novoprotein). ..

    Cell Culture:

    Article Title: ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8 + T cell immunity.
    Article Snippet: .. Briefly, 5 × 106/ml PBMCs were enriched by plastic adherence in six-well plates at 37 °C and 5% CO2 Following 16 h incubation, the adherent cells were cultured in RPMI-1640 medium with 10% FBS, 50 ng/ml human GM-CSF (SJA01; Amoytop), and 10 ng/ml human IL-4 interleukin-4 (GMP-CD03; Novoprotein). ..



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    human interleukin 4 il 4  (Miltenyi Biotec)
    96
    Miltenyi Biotec human interleukin 4 il 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Human Interleukin 4 Il 4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    interleukin 4  (MedChemExpress)
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    MedChemExpress interleukin 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Interleukin 4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    interleukin 4 il 4  (Thermo Fisher)
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    Thermo Fisher interleukin 4 il 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Interleukin 4 Il 4, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human il-4 (interleukin 4) elisa kit  (Guangzhou JET Bio-Filtration)
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    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
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    interleukin 4 il 4  (Miltenyi Biotec)
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    Miltenyi Biotec interleukin 4 il 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Interleukin 4 Il 4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+il+4+interleukin+4/Human+IL-4%2C+premium+grade/pmc12924898-252-34-36
    Average 96 stars, based on 1 article reviews
    interleukin 4 il 4 - by Bioz Stars, 2026-10
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    human interleukin il 4  (Thermo Fisher)
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    Thermo Fisher human interleukin il 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Human Interleukin Il 4, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+il+4+interleukin+4/Interleukin+4%2C+human/10__1097_slash_tp__0000000000005787-63-44-49
    Average 94 stars, based on 1 article reviews
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    interleukin 4  (Miltenyi Biotec)
    96
    Miltenyi Biotec interleukin 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Interleukin 4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+il+4+interleukin+4/Human+IL-4%2C+premium+grade/bio_rxiv__64898__2026__05__13__724773-192-32-34
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    human il 4 interleukin 4  (Novoprotein)
    86
    Novoprotein human il 4 interleukin 4
    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 <t>and</t> <t>IL-4</t> (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.
    Human Il 4 Interleukin 4, supplied by Novoprotein, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+il+4+interleukin+4/4+interleukin/pm42086580-206-43-47
    Average 86 stars, based on 1 article reviews
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    interleukin 4  (RayBiotech inc)
    94
    RayBiotech inc interleukin 4
    PCOS patients have high levels of inflammatory cytokines. (A) Differential heatmaps of the expression of inflammation-related proteins in follicular fluid as detected via the Olink Target 96 Inflammation Panel. Red indicates the upregulated proteins, whereas blue represents the downregulated proteins. GO (B) and KEGG (C) enrichment analyses revealed that the enrichment of differential inflammatory proteins obtained via the Olink Target 96 Inflammation Panel was associated with inflammatory activation pathways in PCOS patients. (D) Spearman correlations between the six most significant inflammatory proteins expressed in the follicular fluid of PCOS patients and clinical and metabolic parameters were analyzed. The heatmap shows the correlation coefficients (r) between circulating inflammatory markers and BMI, hormones, and metabolic variables. Significant correlations ( P < 0.05) are highlighted by asterisks (*). The color gradient reflects the strength and direction of the association (red: positive correlation; blue: negative correlation). (E) Heatmap of the six most significantly expressed DEGs in the peripheral blood of PCOS patients. The columns represent individual genes, and the rows represent samples. Red indicates upregulation, and blue indicates downregulation ( P < 0.05). (F) Violin plots of differentially expressed proteins in peripheral blood from women with PCOS ( P < 0.05). The Y-axis concentration display begins at a value of zero. The external shape of the violin plot is the kernel density estimation and does not indicate the presence of empirically measured negative values. (G) Spearman correlations between six inflammatory proteins (in the peripheral blood) related to PCOS and clinical/metabolic parameters. The heatmap shows the correlation coefficients (r) between inflammatory markers and diagnostic indicators. Significant correlations ( P < 0.05) are indicated in the heatmap. The color gradient represents the strength/direction of the association (red: positive correlation; blue: negative correlation). Abbreviations: DEGs, differentially expressed genes; GO, Gene Ontology; IFN-γ, interferon-γ; IL-2, interleukin-2; IL-10, interleukin-10; IL-4, <t>interleukin-4;</t> IL-6, interleukin-6; IL-17, interleukin-17; KEGG, Kvoto Encyclopedia of Gencs and Genomes and PCOS, polycystic ovary syndrome.
    Interleukin 4, supplied by RayBiotech inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human crp elisa kit  (Elabscience Biotechnology)
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    Elabscience Biotechnology human crp elisa kit
    PCOS patients have high levels of inflammatory cytokines. (A) Differential heatmaps of the expression of inflammation-related proteins in follicular fluid as detected via the Olink Target 96 Inflammation Panel. Red indicates the upregulated proteins, whereas blue represents the downregulated proteins. GO (B) and KEGG (C) enrichment analyses revealed that the enrichment of differential inflammatory proteins obtained via the Olink Target 96 Inflammation Panel was associated with inflammatory activation pathways in PCOS patients. (D) Spearman correlations between the six most significant inflammatory proteins expressed in the follicular fluid of PCOS patients and clinical and metabolic parameters were analyzed. The heatmap shows the correlation coefficients (r) between circulating inflammatory markers and BMI, hormones, and metabolic variables. Significant correlations ( P < 0.05) are highlighted by asterisks (*). The color gradient reflects the strength and direction of the association (red: positive correlation; blue: negative correlation). (E) Heatmap of the six most significantly expressed DEGs in the peripheral blood of PCOS patients. The columns represent individual genes, and the rows represent samples. Red indicates upregulation, and blue indicates downregulation ( P < 0.05). (F) Violin plots of differentially expressed proteins in peripheral blood from women with PCOS ( P < 0.05). The Y-axis concentration display begins at a value of zero. The external shape of the violin plot is the kernel density estimation and does not indicate the presence of empirically measured negative values. (G) Spearman correlations between six inflammatory proteins (in the peripheral blood) related to PCOS and clinical/metabolic parameters. The heatmap shows the correlation coefficients (r) between inflammatory markers and diagnostic indicators. Significant correlations ( P < 0.05) are indicated in the heatmap. The color gradient represents the strength/direction of the association (red: positive correlation; blue: negative correlation). Abbreviations: DEGs, differentially expressed genes; GO, Gene Ontology; IFN-γ, interferon-γ; IL-2, interleukin-2; IL-10, interleukin-10; IL-4, <t>interleukin-4;</t> IL-6, interleukin-6; IL-17, interleukin-17; KEGG, Kvoto Encyclopedia of Gencs and Genomes and PCOS, polycystic ovary syndrome.
    Human Crp Elisa Kit, supplied by Elabscience Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 and IL-4 (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.

    Journal: iScience

    Article Title: In vitro recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform

    doi: 10.1016/j.isci.2026.116416

    Figure Lengend Snippet: Induction of LFs and anti-RABV-G IgG production by SAM-LNP1 in human LF chips (A) Schematic of the LF Chip created with monocytes and conditioned medium from the intramuscular vaccination-mimicking module created with BioRender.com . (B) Representative 3D confocal microscopic stacks showing pseudo-colored follicles (blue) and cell nuclei (green) present within extracellular matrix (ECM) gels cultured for 4 days within a perfused LF Chip when vaccinated with SAM-LNP1 in the absence or presence of IL-2 and IL-4 (SAM-LNP1 + IL-2&IL-4); scale bars, 100 μm. (C) Quantification of the number (left) and size (right) of LFs in LF chips of one donor based on immunostaining followed by confocal imaging. Each data point represents one field of view (left) or an individual follicle (right); 2 independent chips were analyzed per condition. (D) Anti-RABV-G IgG levels in effluents of no treatment LF chips or chips vaccinated with or without IL-2 and IL-4 and cultured for 14 days were detected using a cell-based assay; 3–4 independent chips were analyzed per condition. (E) Quantification of the number (left) and size (right) of LFs in LF chips from four different donors, with each color representing a different donor. Each data point corresponds to one field of view (left) or an individual follicle (right). (F) Anti-RABV-G IgG levels in effluents of LF chips. Each data point represents one chip, with different symbols indicating chips from three independent donors. (G) Anti-RABV-G IgG levels in effluents of LF chips seeded with naive B + bulk T + monocyte mixture. Each data point represents one chip, with different symbols indicating chips from three independent donors. (H) Heatmap showing average log2 fold changes in cytokine levels in the effluents of three LF chips created using bulk lymphocytes from donors whose prior exposure to rabies was unknown, measured using a Luminex Multiplex Assay at various time points (4, 7, 15, 22, and 28 days post-vaccination) compared to the average levels of each cytokine found at day 1. Representative results from one donor are shown in (B)–(D) and (H), with similar outcomes observed in two donors. Data shown are mean ± SD; (C, left; D; and E) one way ANOVA test followed by Tukey’s multiple comparisons test, (C, right; and E) Mann-Whitney U test, (F and G) Welch’s t test.

    Article Snippet: Human Interleukin-4 (IL-4) , Miltenyi Biotec , 130-093-922.

    Techniques: Cell Culture, Immunostaining, Imaging, Cell Based Assay, Luminex, Multiplex Assay, MANN-WHITNEY

    PCOS patients have high levels of inflammatory cytokines. (A) Differential heatmaps of the expression of inflammation-related proteins in follicular fluid as detected via the Olink Target 96 Inflammation Panel. Red indicates the upregulated proteins, whereas blue represents the downregulated proteins. GO (B) and KEGG (C) enrichment analyses revealed that the enrichment of differential inflammatory proteins obtained via the Olink Target 96 Inflammation Panel was associated with inflammatory activation pathways in PCOS patients. (D) Spearman correlations between the six most significant inflammatory proteins expressed in the follicular fluid of PCOS patients and clinical and metabolic parameters were analyzed. The heatmap shows the correlation coefficients (r) between circulating inflammatory markers and BMI, hormones, and metabolic variables. Significant correlations ( P < 0.05) are highlighted by asterisks (*). The color gradient reflects the strength and direction of the association (red: positive correlation; blue: negative correlation). (E) Heatmap of the six most significantly expressed DEGs in the peripheral blood of PCOS patients. The columns represent individual genes, and the rows represent samples. Red indicates upregulation, and blue indicates downregulation ( P < 0.05). (F) Violin plots of differentially expressed proteins in peripheral blood from women with PCOS ( P < 0.05). The Y-axis concentration display begins at a value of zero. The external shape of the violin plot is the kernel density estimation and does not indicate the presence of empirically measured negative values. (G) Spearman correlations between six inflammatory proteins (in the peripheral blood) related to PCOS and clinical/metabolic parameters. The heatmap shows the correlation coefficients (r) between inflammatory markers and diagnostic indicators. Significant correlations ( P < 0.05) are indicated in the heatmap. The color gradient represents the strength/direction of the association (red: positive correlation; blue: negative correlation). Abbreviations: DEGs, differentially expressed genes; GO, Gene Ontology; IFN-γ, interferon-γ; IL-2, interleukin-2; IL-10, interleukin-10; IL-4, interleukin-4; IL-6, interleukin-6; IL-17, interleukin-17; KEGG, Kvoto Encyclopedia of Gencs and Genomes and PCOS, polycystic ovary syndrome.

    Journal: Journal of Advanced Research

    Article Title: Exploration and analysis of methylglyoxal-driven chronic inflammation in polycystic ovary syndrome

    doi: 10.1016/j.jare.2025.08.048

    Figure Lengend Snippet: PCOS patients have high levels of inflammatory cytokines. (A) Differential heatmaps of the expression of inflammation-related proteins in follicular fluid as detected via the Olink Target 96 Inflammation Panel. Red indicates the upregulated proteins, whereas blue represents the downregulated proteins. GO (B) and KEGG (C) enrichment analyses revealed that the enrichment of differential inflammatory proteins obtained via the Olink Target 96 Inflammation Panel was associated with inflammatory activation pathways in PCOS patients. (D) Spearman correlations between the six most significant inflammatory proteins expressed in the follicular fluid of PCOS patients and clinical and metabolic parameters were analyzed. The heatmap shows the correlation coefficients (r) between circulating inflammatory markers and BMI, hormones, and metabolic variables. Significant correlations ( P < 0.05) are highlighted by asterisks (*). The color gradient reflects the strength and direction of the association (red: positive correlation; blue: negative correlation). (E) Heatmap of the six most significantly expressed DEGs in the peripheral blood of PCOS patients. The columns represent individual genes, and the rows represent samples. Red indicates upregulation, and blue indicates downregulation ( P < 0.05). (F) Violin plots of differentially expressed proteins in peripheral blood from women with PCOS ( P < 0.05). The Y-axis concentration display begins at a value of zero. The external shape of the violin plot is the kernel density estimation and does not indicate the presence of empirically measured negative values. (G) Spearman correlations between six inflammatory proteins (in the peripheral blood) related to PCOS and clinical/metabolic parameters. The heatmap shows the correlation coefficients (r) between inflammatory markers and diagnostic indicators. Significant correlations ( P < 0.05) are indicated in the heatmap. The color gradient represents the strength/direction of the association (red: positive correlation; blue: negative correlation). Abbreviations: DEGs, differentially expressed genes; GO, Gene Ontology; IFN-γ, interferon-γ; IL-2, interleukin-2; IL-10, interleukin-10; IL-4, interleukin-4; IL-6, interleukin-6; IL-17, interleukin-17; KEGG, Kvoto Encyclopedia of Gencs and Genomes and PCOS, polycystic ovary syndrome.

    Article Snippet: The levels of inflammatory factors, including interferon-γ (IFN-γ; VAL104C, Novus Biologicals, USA), interleukin-2 (IL-2; ELH-IL2, RayBiotech, USA), interleukin-4 (IL-4; ELH-IL4, RayBiotech), interleukin-6 (IL-6; ELH-IL6, RayBiotech), interleukin-10 (IL-10; ELH-IL10, RayBiotech), and interleukin-17A (IL-17A; ELH-IL17, RayBiotech), were also quantified via ELISA.

    Techniques: Expressing, Activation Assay, Concentration Assay, Diagnostic Assay

    RCS models of the associations between serum and follicular fluid methylglyoxal and inflammation-related factor levels.Association of follicular fluid methylglyoxal levels with (A) IL-8, (B) IL-6, (C) FGF-23, (D) HGF, (E) UPA, and (F) MCP-4 levels via RCS analysis in PCOS patients and association of serum methylglyoxal levels with (G) INF-γ, (H) IL-2, (I) IL-10, (J) IL-4, (K) IL-6,and (L) IL-17A levels via RCS analysis in PCOS patients. Associations between serum methylglyoxal levels and (M) WBCs, (N) neutrophils, (O) lymphocytes, and (P) the N/L ratio determined via RCS analysis in PCOS patients. Abbreviations: FGF-23, fibroblast growth factor; HGF, hepatocyte growth factor; IL-2, interleukin-2; IL-4, interleukin-4; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; IL-17A, interleukin-17A; IFN-γ, interferon-γ; MCP-4, monocyte chemotactic protein; N/L, the ratio of neutrophils/lymphocytes; PCOS, polycystic ovary syndrome; RCS, restricted cubic spline; UPA, urokinase-type plasminogen activator and WBCs, white blood cells.

    Journal: Journal of Advanced Research

    Article Title: Exploration and analysis of methylglyoxal-driven chronic inflammation in polycystic ovary syndrome

    doi: 10.1016/j.jare.2025.08.048

    Figure Lengend Snippet: RCS models of the associations between serum and follicular fluid methylglyoxal and inflammation-related factor levels.Association of follicular fluid methylglyoxal levels with (A) IL-8, (B) IL-6, (C) FGF-23, (D) HGF, (E) UPA, and (F) MCP-4 levels via RCS analysis in PCOS patients and association of serum methylglyoxal levels with (G) INF-γ, (H) IL-2, (I) IL-10, (J) IL-4, (K) IL-6,and (L) IL-17A levels via RCS analysis in PCOS patients. Associations between serum methylglyoxal levels and (M) WBCs, (N) neutrophils, (O) lymphocytes, and (P) the N/L ratio determined via RCS analysis in PCOS patients. Abbreviations: FGF-23, fibroblast growth factor; HGF, hepatocyte growth factor; IL-2, interleukin-2; IL-4, interleukin-4; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; IL-17A, interleukin-17A; IFN-γ, interferon-γ; MCP-4, monocyte chemotactic protein; N/L, the ratio of neutrophils/lymphocytes; PCOS, polycystic ovary syndrome; RCS, restricted cubic spline; UPA, urokinase-type plasminogen activator and WBCs, white blood cells.

    Article Snippet: The levels of inflammatory factors, including interferon-γ (IFN-γ; VAL104C, Novus Biologicals, USA), interleukin-2 (IL-2; ELH-IL2, RayBiotech, USA), interleukin-4 (IL-4; ELH-IL4, RayBiotech), interleukin-6 (IL-6; ELH-IL6, RayBiotech), interleukin-10 (IL-10; ELH-IL10, RayBiotech), and interleukin-17A (IL-17A; ELH-IL17, RayBiotech), were also quantified via ELISA.

    Techniques: